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Protection from Rapamycin-induced apoptosis by IGF-1 is Partially Dependent on PKC Signaling

Rapamycin induced apoptosis in sarcoma cells is inhibited by IGF-1 through a signaling pathway independent of Ras-Erk-1/2 and Akt (Thimmaiah et al. Cancer Res. 63:364, 2003). IGF-1 induces Bad phosphorylation (S112, S136, S155) in a pathway involving PI3K and PKC (μ, ε, or θ) resulting in sequesteri...

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Detalhes bibliográficos
Main Authors: Thimmaiah, Kuntebommanahalli N., Easton, John B., Houghton, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003869/
https://ncbi.nlm.nih.gov/pubmed/20179209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-3693
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