Yin Yang 1 deficiency in skeletal muscle protects against rapamycin-induced diabetic-like symptoms through activation of insulin/IGF signaling

Rapamycin and derivatives are mTOR inhibitors used in tissue transplantation and cancer therapy. A percentage of patients treated with these inhibitors develop diabetic-like symptoms but the molecular mechanisms are unknown. We show here that chronic rapamycin treatment in mice leads to insulin resi...

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Detalhes bibliográficos
Main Authors: Blättler, Sharon M., Cunningham, John T., Verdeguer, Francisco, Chim, Helen, Haas, Wilhelm, Liu, Huifei, Romanino, Klaas, Rüegg, Markus A., Gygi, Steven P., Shi, Yang, Puigserver, Pere
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324784/
https://ncbi.nlm.nih.gov/pubmed/22482732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.03.008
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