PKCα and HMGB1 antagonistically control hydrogen peroxide-induced poly-ADP-ribose formation

Harmful oxidation of proteins, lipids and nucleic acids is observed when reactive oxygen species (ROS) are produced excessively and/or the antioxidant capacity is reduced, causing ‘oxidative stress’. Nuclear poly-ADP-ribose (PAR) formation is thought to be induced in response to oxidative DNA damage...

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Bibliografische gegevens
Gepubliceerd in:Nucleic Acids Res
Hoofdauteurs: Andersson, Anneli, Bluwstein, Andrej, Kumar, Nitin, Teloni, Federico, Traenkle, Jens, Baudis, Michael, Altmeyer, Matthias, Hottiger, Michael O.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2016
Onderwerpen:
Gene regulation, Chromatin and Epigenetics
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027479/
https://ncbi.nlm.nih.gov/pubmed/27198223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw442
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