Human VRK2 modulates apoptosis by interaction with Bcl-xL and regulation of BAX gene expression

VRK2 is a novel Ser-Thr kinase whose VRK2A isoform is located in the endoplasmic reticulum and mitochondrial membranes. We have studied the potential role that VRK2A has in the regulation of mitochondrial-mediated apoptosis. VRK2A can regulate the intrinsic apoptotic pathway in two different ways. T...

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Detalhes bibliográficos
Main Authors: Monsalve, D M, Merced, T, Fernández, I F, Blanco, S, Vázquez-Cedeira, M, Lazo, P A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734818/
https://ncbi.nlm.nih.gov/pubmed/23449449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.40
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