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Oxime-based click chemistry in the development of 3-isoxazolecarboxylic acid-containing inhibitors of Yersinia pestis protein tyrosine phosphatase, YopH

Pathogenicity of Yersinia pestis (Y. pestis) relies on several effector proteins, including YopH, a protein-tyrosine phosphatase. Previously, we screened a library of analogues based on the ubiquitous PTP substrate, p-nitrophenylphosphate (pNPP) and found that incorporation of a 3-phenyl substituent...

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Autors principals: Bahta, Medhanit, Burke, Terrence R.
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734799/
https://ncbi.nlm.nih.gov/pubmed/21671403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201100200
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