Antitumor Effects of Chimeric Receptor Engineered Human T Cells Directed to Tumor Stroma

Cancer-associated fibroblasts (CAFs), the principle component of the tumor-associated stroma, form a highly protumorigenic and immunosuppressive microenvironment that mediates therapeutic resistance. Co-targeting CAFs in addition to cancer cells may therefore augment the antitumor response. Fibrobla...

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Autori principali: Kakarla, Sunitha, Chow, Kevin KH, Mata, Melinda, Shaffer, Donald R, Song, Xiao-Tong, Wu, Meng-Fen, Liu, Hao, Wang, Lisa L, Rowley, David R, Pfizenmaier, Klaus, Gottschalk, Stephen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734659/
https://ncbi.nlm.nih.gov/pubmed/23732988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.110
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