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A Vaccine That Co-Targets Tumor Cells and Cancer Associated Fibroblasts Results in Enhanced Antitumor Activity by Inducing Antigen Spreading

Dendritic cell (DC) vaccines targeting only cancer cells have produced limited antitumor activity in most clinical studies. Targeting cancer-associated fibroblasts (CAFs) in addition to cancer cells may enhance antitumor effects, since CAFs, the central component of the tumor stroma, directly suppor...

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Detalhes bibliográficos
Main Authors: Gottschalk, Stephen, Yu, Feng, Ji, Minjun, Kakarla, Sunitha, Song, Xiao-Tong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3861387/
https://ncbi.nlm.nih.gov/pubmed/24349329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0082658
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