Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs

In response to inflammation, pancreatic acinar cells can undergo acinar-to-ductal metaplasia (ADM), a reprogramming event that induces transdifferentiation to a ductlike phenotype and, in the context of additional oncogenic stimulation, contributes to development of pancreatic cancer. The signaling...

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Autori principali: Liou, Geou-Yarh, Döppler, Heike, Necela, Brian, Krishna, Murli, Crawford, Howard C., Raimondo, Massimo, Storz, Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2013
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734091/
https://ncbi.nlm.nih.gov/pubmed/23918941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201301001
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