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Mutant Kras-induced expression of ICAM-1 in pancreatic acinar cells causes attraction of macrophages to expedite the formation of precancerous lesions

Desmoplasia and an inflammatory environment are defining features of pancreatic cancer. Unclear is how pancreatic cells that undergo oncogenic transformation can crosstalk with immune cells and how this contributes to the development of pancreatic lesions. Here we demonstrate that pancreatic acinar...

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Publicado en:Cancer Discov
Autores principales: Liou, Geou-Yarh, Döppler, Heike, Necela, Brian, Edenfield, Brandy, Zhang, Lizhi, Dawson, David W., Storz, Peter
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4293204/
https://ncbi.nlm.nih.gov/pubmed/25361845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-0474
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