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Structure–function correlations derived from faster variants of a RNA ligase deoxyribozyme
We previously reported the in vitro selection of several Mg(2+)-dependent deoxyribozymes (DNA enzymes) that synthesize a 2′–5′ RNA linkage from a 2′,3′-cyclic phosphate and a 5′-hydroxyl. Here we subjected the 9A2 deoxyribozyme to re-selection for improved ligation rate. We found two new DNA enzymes...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC373398/ https://ncbi.nlm.nih.gov/pubmed/14960718 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh263 |
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