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TAp73 enhances the pentose phosphate pathway and supports cell proliferation

TAp73 is a structural homologue of the pre-eminent tumor suppressor p53. However, unlike p53, TAp73 is rarely mutated, and instead is frequently over-expressed in human tumors. It remains unclear whether TAp73 affords an advantage to tumor cells and if so, what is the underlying mechanism. Here we s...

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Dettagli Bibliografici
Autori principali: Du, Wenjing, Jiang, Peng, Mancuso, Anthony, Stonestrom, Aaron, Brewer, Michael D., Minn, Andy J., Mak, Tak W., Wu, Mian, Yang, Xiaolu
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3733810/
https://ncbi.nlm.nih.gov/pubmed/23811687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2789
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