A Human In Vitro Whole Blood Assay to Predict the Systemic Cytokine Response to Therapeutic Oligonucleotides Including siRNA

Therapeutic oligonucleotides including siRNA and immunostimulatory ligands of Toll-like receptors (TLR) or RIG-I like helicases (RLH) are a promising novel class of drugs. They are in clinical development for a broad spectrum of applications, e.g. as adjuvants in vaccines and for the immunotherapy o...

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Autors principals: Coch, Christoph, Lück, Christian, Schwickart, Anna, Putschli, Bastian, Renn, Marcel, Höller, Tobias, Barchet, Winfried, Hartmann, Gunther, Schlee, Martin
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3733725/
https://ncbi.nlm.nih.gov/pubmed/23940691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071057
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