Polymersome delivery of siRNA and antisense oligonucleotides

siRNA and antisense oligonucleotides, AON, have similar size and negative charge and are often packaged for in vitro delivery with cationic lipids or polymers–but exposed positive charge is problematic in vivo. Here we demonstrate loading and functional delivery of RNAi and AON with non-ionic, nano-...

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Bibliografske podrobnosti
Main Authors: Kim, Younghoon, Tewari, Manorama, Pajerowski, J. David, Cai, Shenshen, Sen, Shamik, Williams, Jason, Sirsi, Shashank, Lutz, Gordon, Discher, Dennis E.
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740336/
https://ncbi.nlm.nih.gov/pubmed/19084037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2008.10.020
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