Polymersome delivery of siRNA and antisense oligonucleotides

siRNA and antisense oligonucleotides, AON, have similar size and negative charge and are often packaged for in vitro delivery with cationic lipids or polymers–but exposed positive charge is problematic in vivo. Here we demonstrate loading and functional delivery of RNAi and AON with non-ionic, nano-...

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Hlavní autoři: Kim, Younghoon, Tewari, Manorama, Pajerowski, J. David, Cai, Shenshen, Sen, Shamik, Williams, Jason, Sirsi, Shashank, Lutz, Gordon, Discher, Dennis E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740336/
https://ncbi.nlm.nih.gov/pubmed/19084037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2008.10.020
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