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Multiple Reaction Monitoring to Identify Site-Specific Troponin I Phosphorylated Residues in the Failing Human Heart

BACKGROUND: Human cardiac troponin I is known to be phosphorylated at multiple amino acid residues by several kinases. Advances in mass spectrometry allow sensitive detection of known and novel phosphorylation sites and measurement of the level of phosphorylation simultaneously at each site in myoca...

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Detalhes bibliográficos
Main Authors: Zhang, Pingbo, Kirk, Jonathan A., Ji, Weihua, dos Remedios, Cristobal G., Kass, David A., Van Eyk, Jennifer E., Murphy, Anne M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3733556/
https://ncbi.nlm.nih.gov/pubmed/22972900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.112.096388
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