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Impaired Priming and Activation of the Neutrophil NADPH Oxidase in Patients with IRAK4- or NEMO-deficiency
The NADPH oxidase (NOX), an oligomeric enzyme, plays a key role in polymorphonuclear neutrophil (PMN)-mediated host defense by producing cytotoxic superoxide anion (O(2)(.−)). Whereas in vitro and biochemical studies have examined the assembly and activation of this important host immune defense sys...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3733113/ https://ncbi.nlm.nih.gov/pubmed/19414794 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0802512 |
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