Priming of neutrophil oxidative burst in diabetes requires preassembly of the NADPH oxidase

Hyperglycemia associated with diabetes mellitus results in the priming of neutrophils leading to oxidative stress that is, in part, responsible for diabetic complications. p47(phox), a NADPH oxidase cytosolic subunit, is a key protein in the assembly of the NADPH oxidase leading to superoxide genera...

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Auteurs principaux: Omori, Kazuhiro, Ohira, Taisuke, Uchida, Yushi, Ayilavarapu, Srinivas, Batista, Eraldo L., Yagi, Motohiko, Iwata, Tomoyuki, Liu, Hongsheng, Hasturk, Hatice, Kantarci, Alpdogan, Van Dyke, Thomas E.
Format: Artigo
Langue:Inglês
Publié: The Society for Leukocyte Biology 2008
Sujets:
Receptors, Signal Transduction, and Genes
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774791/
https://ncbi.nlm.nih.gov/pubmed/18390927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.1207832
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