Apoptosis of Insulin-Secreting Cells Induced by Endoplasmic Reticulum Stress Is Amplified by Overexpression of Group VIA Calcium-Independent Phospholipase A(2) (iPLA(2)β) and Suppressed by Inhibition of iPLA(2)β

The death of insulin-secreting β-cells that causes type I diabetes mellitus (DM) occurs in part by apoptosis, and apoptosis also contributes to progressive β-cell dysfunction in type II DM. Recent reports indicate that ER stress-induced apoptosis contributes to β-cell loss in diabetes. Agents that d...

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Autores principales: Ramanadham, Sasanka, Hsu, Fong-Fu, Zhang, Sheng, Jin, Chun, Bohrer, Alan, Song, Haowei, Bao, Shunzhong, Ma, Zhongmin, Turk, John
Formato: Artigo
Lenguaje:Inglês
Publicado: 2004
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3732319/
https://ncbi.nlm.nih.gov/pubmed/14744135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi035536m
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