Adenoviral Transduction of Human Acid Sphingomyelinase into Neo-Angiogenic Endothelium Radiosensitizes Tumor Cure

These studies define a new mechanism-based approach to radiosensitize tumor cure by single dose radiotherapy (SDRT). Published evidence indicates that SDRT induces acute microvascular endothelial apoptosis initiated via acid sphingomyelinase (ASMase) translocation to the external plasma membrane. En...

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Detalhes bibliográficos
Main Authors: Stancevic, Branka, Varda-Bloom, Nira, Cheng, Jin, Fuller, John D., Rotolo, Jimmy A., García-Barros, Mónica, Feldman, Regina, Rao, Shyam, Weichselbaum, Ralph R., Harats, Dror, Haimovitz-Friedman, Adriana, Fuks, Zvi, Sadelain, Michel, Kolesnick, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3732255/
https://ncbi.nlm.nih.gov/pubmed/23936314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069025
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