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Gemcitabine kills proliferating endothelial cells exclusively via acid sphingomyelinase activation
Gemcitabine is a widely-used anti-cancer drug with a well-defined mechanism of action in normal and transformed epithelial cells. However, its effect on endothelial cells is largely unknown. Acid sphingomyelinase (ASMase) is highly expressed in endothelial cells, converting plasma membrane sphingomy...
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| Veröffentlicht in: | Cell Signal |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5565230/ https://ncbi.nlm.nih.gov/pubmed/28238856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2017.02.021 |
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