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Gemcitabine kills proliferating endothelial cells exclusively via acid sphingomyelinase activation
Gemcitabine is a widely-used anti-cancer drug with a well-defined mechanism of action in normal and transformed epithelial cells. However, its effect on endothelial cells is largely unknown. Acid sphingomyelinase (ASMase) is highly expressed in endothelial cells, converting plasma membrane sphingomy...
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| Publié dans: | Cell Signal |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5565230/ https://ncbi.nlm.nih.gov/pubmed/28238856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2017.02.021 |
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