Oncogenic Mutations of p110α Isoform of PI 3-Kinase Upregulate Its Protein Kinase Activity

In addition to lipid kinase activity, the class-I PI 3-kinases also function as protein kinases targeting regulatory autophosphorylation sites and exogenous substrates. The latter include a recently identified regulatory phosphorylation of the GM-CSF/IL-3 βc receptor contributing to survival of acut...

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Bibliografiske detaljer
Main Authors: Buchanan, Christina M., Dickson, James M. J., Lee, Woo-Jeong, Guthridge, Mark A., Kendall, Jackie D., Shepherd, Peter R.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3731339/
https://ncbi.nlm.nih.gov/pubmed/23936502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071337
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