K(+) efflux is the Common Trigger of NLRP3 inflammasome Activation by Bacterial Toxins and Particulate Matter

The NLRP3 inflammasome is an important component of the innate immune system. However, its mechanism of activation remains largely unknown. We show that NLRP3 activators including bacterial pore-forming toxins, nigericin, ATP and particulate matter caused mitochondrial perturbation or the opening of...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Muñoz-Planillo, Raúl, Kuffa, Peter, Martínez-Colón, Giovanny, Smith, Brenna L., Rajendiran, Thekkelnaycke M., Núñez, Gabriel
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3730833/
https://ncbi.nlm.nih.gov/pubmed/23809161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2013.05.016
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge