K(+) efflux is the Common Trigger of NLRP3 inflammasome Activation by Bacterial Toxins and Particulate Matter

The NLRP3 inflammasome is an important component of the innate immune system. However, its mechanism of activation remains largely unknown. We show that NLRP3 activators including bacterial pore-forming toxins, nigericin, ATP and particulate matter caused mitochondrial perturbation or the opening of...

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Bibliographic Details
Main Authors: Muñoz-Planillo, Raúl, Kuffa, Peter, Martínez-Colón, Giovanny, Smith, Brenna L., Rajendiran, Thekkelnaycke M., Núñez, Gabriel
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3730833/
https://ncbi.nlm.nih.gov/pubmed/23809161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2013.05.016
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