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Anti-CD3 treatment cures PDL1−/−.NOD mice of diabetes but precipitates fatal myocarditis

Anti-CD3 mAb is an effective therapy that can reverse diabetes in NOD mice and has therapeutic potential in patients with type 1 diabetes (T1D). We administered anti-CD3 to PDL1−/−.NOD mice in order to determine whether this treatment would reverse the development of diabetes in these mice. Mice inj...

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Main Authors: Mfarrej, Bechara, Keir, Mary, Dada, Shirine, Trikudanathan, Subbulaxmi, Sayegh, Mohamed, Sharpe, Arlene H., Guleria, Indira
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3730534/
https://ncbi.nlm.nih.gov/pubmed/21498129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2011.03.011
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