CpG islands influence chromatin structure via the CpG-binding protein Cfp1

CpG islands (CGIs) are prominent in the mammalian genome owing to their GC-rich base composition and high density of CpG dinucleotides(1,2). Most human gene promoters are embedded within CGIs that lack DNA methylation and coincide with sites of histone H3 lysine 4 trimethylation (H3K4me3), irrespect...

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Hauptverfasser: Thomson, John P., Skene, Peter J., Selfridge, Jim, Clouaire, Thomas, Guy, Jacky, Webb, Shaun, Kerr, Alastair R. W., Deaton, Aimée, Andrews, Rob, James, Keith D., Turner, Daniel J., Illingworth, Robert, Bird, Adrian
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3730110/
https://ncbi.nlm.nih.gov/pubmed/20393567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08924
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