Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation

Aberrant Wnt signaling can drive cancer development. In many cancer types, the genetic basis of Wnt pathway activation remains incompletely understood. Here, we report recurrent somatic mutations of the Drosophila tumor suppressor-related gene FAT1 in glioblastoma (20.5%), colorectal cancer (7.7%),...

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Hauptverfasser: Morris, Luc G.T., Kaufman, Andrew M., Gong, Yongxing, Ramaswami, Deepa, Walsh, Logan A., Turcan, Sevin, Eng, Stephanie, Kannan, Kasthuri, Zou, Yilong, Peng, Luke, Banuchi, Victoria E., Paty, Phillip, Zeng, Zhaoshi, Vakiani, Efsevia, Solit, David, Singh, Bhuvanesh, Ganly, Ian, Liau, Linda, Cloughesy, Timothy C., Mischel, Paul S., Mellinghoff, Ingo K., Chan, Timothy A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3729040/
https://ncbi.nlm.nih.gov/pubmed/23354438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2538
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