Genomic dissection of the epidermal growth factor receptor (EGFR)/PI3K pathway reveals frequent deletion of the EGFR phosphatase PTPRS in head and neck cancers

Activation of the PI3K and epidermal growth factor receptor (EGFR) pathway is able to drive oncogenesis in multiple human cancers, including head and neck squamous cell carcinoma. Targeted agents such as cetuximab and erlotinib are currently used in patients with head and neck squamous cell carcinom...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Morris, Luc G. T., Taylor, Barry S., Bivona, Trever G., Gong, Yongxing, Eng, Stephanie, Brennan, Cameron W., Kaufman, Andrew, Kastenhuber, Edward R., Banuchi, Victoria E., Singh, Bhuvanesh, Heguy, Adriana, Viale, Agnes, Mellinghoff, Ingo K., Huse, Jason, Ganly, Ian, Chan, Timothy A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2011
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223475/
https://ncbi.nlm.nih.gov/pubmed/22065749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111963108
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