Genomic dissection of the epidermal growth factor receptor (EGFR)/PI3K pathway reveals frequent deletion of the EGFR phosphatase PTPRS in head and neck cancers

Activation of the PI3K and epidermal growth factor receptor (EGFR) pathway is able to drive oncogenesis in multiple human cancers, including head and neck squamous cell carcinoma. Targeted agents such as cetuximab and erlotinib are currently used in patients with head and neck squamous cell carcinom...

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Detalhes bibliográficos
Main Authors: Morris, Luc G. T., Taylor, Barry S., Bivona, Trever G., Gong, Yongxing, Eng, Stephanie, Brennan, Cameron W., Kaufman, Andrew, Kastenhuber, Edward R., Banuchi, Victoria E., Singh, Bhuvanesh, Heguy, Adriana, Viale, Agnes, Mellinghoff, Ingo K., Huse, Jason, Ganly, Ian, Chan, Timothy A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223475/
https://ncbi.nlm.nih.gov/pubmed/22065749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111963108
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