Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation

Aberrant Wnt signaling can drive cancer development. In many cancer types, the genetic basis of Wnt pathway activation remains incompletely understood. Here, we report recurrent somatic mutations of the Drosophila tumor suppressor-related gene FAT1 in glioblastoma (20.5%), colorectal cancer (7.7%),...

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Auteurs principaux: Morris, Luc G.T., Kaufman, Andrew M., Gong, Yongxing, Ramaswami, Deepa, Walsh, Logan A., Turcan, Sevin, Eng, Stephanie, Kannan, Kasthuri, Zou, Yilong, Peng, Luke, Banuchi, Victoria E., Paty, Phillip, Zeng, Zhaoshi, Vakiani, Efsevia, Solit, David, Singh, Bhuvanesh, Ganly, Ian, Liau, Linda, Cloughesy, Timothy C., Mischel, Paul S., Mellinghoff, Ingo K., Chan, Timothy A.
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3729040/
https://ncbi.nlm.nih.gov/pubmed/23354438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2538
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