Augmenting Autophagy to Treat Acute Kidney Injury during Endotoxemia in Mice

OBJECTIVE: To determine that 1) an age-dependent loss of inducible autophagy underlies the failure to recover from AKI in older, adult animals during endotoxemia, and 2) pharmacologic induction of autophagy, even after established endotoxemia, is of therapeutic utility in facilitating renal recovery...

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Autors principals: Howell, Gina M., Gomez, Hernando, Collage, Richard D., Loughran, Patricia, Zhang, Xianghong, Escobar, Daniel A., Billiar, Timothy R., Zuckerbraun, Brian S., Rosengart, Matthew R.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3728340/
https://ncbi.nlm.nih.gov/pubmed/23936035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069520
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