Augmenting Autophagy to Treat Acute Kidney Injury during Endotoxemia in Mice

OBJECTIVE: To determine that 1) an age-dependent loss of inducible autophagy underlies the failure to recover from AKI in older, adult animals during endotoxemia, and 2) pharmacologic induction of autophagy, even after established endotoxemia, is of therapeutic utility in facilitating renal recovery...

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Detalhes bibliográficos
Main Authors: Howell, Gina M., Gomez, Hernando, Collage, Richard D., Loughran, Patricia, Zhang, Xianghong, Escobar, Daniel A., Billiar, Timothy R., Zuckerbraun, Brian S., Rosengart, Matthew R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3728340/
https://ncbi.nlm.nih.gov/pubmed/23936035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069520
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