Augmenting Autophagy to Treat Acute Kidney Injury during Endotoxemia in Mice

OBJECTIVE: To determine that 1) an age-dependent loss of inducible autophagy underlies the failure to recover from AKI in older, adult animals during endotoxemia, and 2) pharmacologic induction of autophagy, even after established endotoxemia, is of therapeutic utility in facilitating renal recovery...

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Détails bibliographiques
Auteurs principaux: Howell, Gina M., Gomez, Hernando, Collage, Richard D., Loughran, Patricia, Zhang, Xianghong, Escobar, Daniel A., Billiar, Timothy R., Zuckerbraun, Brian S., Rosengart, Matthew R.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2013
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3728340/
https://ncbi.nlm.nih.gov/pubmed/23936035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069520
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