Lentiviral Vector Mediated Thymidine Kinase Expression in Pluripotent Stem Cells Enables Removal of Tumorigenic Cells

Embryonic stem cells (ES) and induced pluripotent stem (iPS) cells represent promising tools for cell-based therapies and regenerative medicine. Nevertheless, implantation of ES cell derived differentiated cells holds the risk of teratoma formation due to residual undifferentiated cells. In order to...

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Main Authors: Lim, Tiong-Ti, Geisen, Caroline, Hesse, Michael, Fleischmann, Bernd K., Zimmermann, Katrin, Pfeifer, Alexander
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3728319/
https://ncbi.nlm.nih.gov/pubmed/23936225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070543
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