Impaired contractile function due to decreased cardiac myosin binding protein C content in the sarcomere

Mutations in cardiac myosin binding protein C (MyBP-C) are a common cause of familial hypertrophic cardiomyopathy (FHC). The majority of MyBP-C mutations are expected to reduce MyBP-C expression; however, the consequences of MyBP-C deficiency on the regulation of myofilament function, Ca(2+) homeost...

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Detalhes bibliográficos
Main Authors: Cheng, Y., Wan, X., McElfresh, T. A., Chen, X., Gresham, K. S., Rosenbaum, D. S., Chandler, M. P., Stelzer, J. E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
Assuntos:
Muscle Mechanics and Ventricular Function
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3727108/
https://ncbi.nlm.nih.gov/pubmed/23666674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00929.2012
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