Enhanced Ca(2+) binding of cardiac troponin reduces sarcomere length dependence of contractile activation independently of strong crossbridges

Calcium sensitivity of the force-pCa relationship depends strongly on sarcomere length (SL) in cardiac muscle and is considered to be the cellular basis of the Frank-Starling law of the heart. SL dependence may involve changes in myofilament lattice spacing and/or myosin crossbridge orientation to i...

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Main Authors: Korte, F. Steven, Feest, Erik R., Razumova, Maria V., Tu, An-Yue, Regnier, Michael
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2012
Assuntos:
Muscle Mechanics and Ventricular Function
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469702/
https://ncbi.nlm.nih.gov/pubmed/22865385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00395.2012
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