Independent Modulation of Contractile Performance by Cardiac Troponin I Ser43 and Ser45 in the Dynamic Sarcomere

Protein kinase C (PKC) targets cardiac troponin I (cTnI) S43/45 for phosphorylation in addition to other residues. During heart failure, cTnI S43/45 phosphorylation is elevated, and yet there is ongoing debate about its functional role due, in part, to the emergence of complex phenotypes in animal m...

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Vydáno v:J Mol Cell Cardiol
Hlavní autoři: Lang, Sarah E, Schwank, Jennifer, Stevenson, Tamara K, Jensen, Mark A, Westfall, Margaret V
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301988/
https://ncbi.nlm.nih.gov/pubmed/25481661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2014.11.022
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