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Enhanced Ca(2+) binding of cardiac troponin reduces sarcomere length dependence of contractile activation independently of strong crossbridges
Calcium sensitivity of the force-pCa relationship depends strongly on sarcomere length (SL) in cardiac muscle and is considered to be the cellular basis of the Frank-Starling law of the heart. SL dependence may involve changes in myofilament lattice spacing and/or myosin crossbridge orientation to i...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Physiological Society
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3469702/ https://ncbi.nlm.nih.gov/pubmed/22865385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00395.2012 |
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