An Activating Mutation Reveals a Second Binding Mode of the Integrin α2 I Domain to the GFOGER Motif in Collagens

The GFOGER motif in collagens (O denotes hydroxyproline) represents a high-affinity binding site for all collagen-binding integrins. Other GxOGER motifs require integrin activation for maximal binding. The E318W mutant of the integrin α2β1 I domain displays a relaxed collagen specificity, typical of...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Main Authors: Carafoli, Federico, Hamaia, Samir W., Bihan, Dominique, Hohenester, Erhard, Farndale, Richard W.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2013
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726769/
https://ncbi.nlm.nih.gov/pubmed/23922814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069833
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla