Loading...
An Activating Mutation Reveals a Second Binding Mode of the Integrin α2 I Domain to the GFOGER Motif in Collagens
The GFOGER motif in collagens (O denotes hydroxyproline) represents a high-affinity binding site for all collagen-binding integrins. Other GxOGER motifs require integrin activation for maximal binding. The E318W mutant of the integrin α2β1 I domain displays a relaxed collagen specificity, typical of...
Na minha lista:
| Main Authors: | , , , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2013
|
| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3726769/ https://ncbi.nlm.nih.gov/pubmed/23922814 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069833 |
| Tags: |
Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!
|