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Functional consequences of retro-inverso isomerization of a miniature protein inhibitor of the p53-MDM2 interaction(1)

Peptide retro-inverso isomerization is thought to be functionally neutral and has been widely used as a tool for designing proteolytically stable D-isomers to recapitulate biological activities of their parent L-peptides. Despite success in a wide range of applications, exceptions amply exist that c...

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Autori principali: Li, Chong, Zhan, Changyou, Zhao, Le, Chen, Xishan, Lu, Wei-Yue, Lu, Wuyuan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726206/
https://ncbi.nlm.nih.gov/pubmed/23660015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.04.039
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