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Functional consequences of retro-inverso isomerization of a miniature protein inhibitor of the p53-MDM2 interaction(1)
Peptide retro-inverso isomerization is thought to be functionally neutral and has been widely used as a tool for designing proteolytically stable D-isomers to recapitulate biological activities of their parent L-peptides. Despite success in a wide range of applications, exceptions amply exist that c...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3726206/ https://ncbi.nlm.nih.gov/pubmed/23660015 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.04.039 |
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