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Novel bis-2,2,6,6-tetramethylpiperidine (bis-TMP) and bis-mecamylamine antagonists at neuronal nicotinic receptors mediating nicotine-evoked dopamine release

By linking two or three mecamylamine or 2,2,6,6-tetramethylpiperidine (TMP) molecules together via a linear lipophilic bis-methylene linker or a specially designed conformationally restricted tris-linker, a series of bis- and tris-tertiary amine analogs has been synthesized and evaluated as potent a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhang, Zhenfa, Pivavarchyk, Marharyta, Subramanian, K. Leela, Deaciuc, A. Gabriela, Dwoskin, Linda P., Crooks, Peter A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726006/
https://ncbi.nlm.nih.gov/pubmed/20079634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.12.089
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