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Novel bis-, tris-, and tetrakis-tertiary amino analogues as antagonists at neuronal nicotinic receptors that mediate nicotine-evoked dopamine release

A series of tertiary amine analogues derived from lead azaaromatic quaternary ammonium salts has been designed and synthesized. The preliminary structure-activity relationships of these new analogues suggest that such tertiary amine analogues, which potently inhibit nicotine-evoked dopamine release...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Zhang, Zhenfa, Zheng, Guangrong, Pivavarchyk, Marharyta, Deaciuc, A. Gabriela, Dwoskin, Linda P., Crooks, Peter A.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725996/
https://ncbi.nlm.nih.gov/pubmed/21147530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.11.070
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