Selective Inhibition of Acetylcholine-Evoked Responses of α7 Neuronal Nicotinic Acetylcholine Receptors by Novel tris- and tetrakis-Azaaromatic Quaternary Ammonium Antagonists

A family of 20 tris-azaaromatic quaternary ammonium (AQA) compounds were tested for their inhibition of α7 nicotinic acetylcholine receptors (nAChRs) expressed in Xenopus laevis oocytes. The potency of inhibitory activity was related to the hydrophobic character of the tris head groups. Two tris-AQA...

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Bibliographic Details
Main Authors: López-Hernández, Gretchen Y., Thinschmidt, Jeffrey S., Zheng, Guangrong, Zhang, Zhenfa, Crooks, Peter A., Dwoskin, Linda P., Papke, Roger L.
Format: Artigo
Language:Inglês
Published: American Society for Pharmacology and Experimental Therapeutics 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730394/
https://ncbi.nlm.nih.gov/pubmed/19556356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.056176
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