bis-Azaaromatic quaternary ammonium salts as ligands for the blood-brain barrier choline transporter

A series of bis-azaaromatic quaternary ammonium compounds containing flexible polymethylenic linkers as well as conformationally restricted linkers were evaluated for their affinity for the blood-brain barrier choline transporter (BBB-ChT). The preliminary structure-activity relationships obtained f...

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Hauptverfasser: Zheng, Guangrong, Zhang, Zhenfa, Lockman, Paul R., Geldenhuys, Werner J., Allen, David D., Dwoskin, Linda P., Crooks, Peter A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725989/
https://ncbi.nlm.nih.gov/pubmed/20462759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.04.098
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