tetrakis-Azaaromatic quaternary ammonium salts: Novel subtype-selective antagonists at neuronal nicotinic receptors that mediate nicotine-evoked dopamine release

A series of tetrakis-azaaromatic quaternary ammonium salts was synthesized in order to identify compounds with higher affinity and selectivity as antagonists at neuronal nicotinic receptor subtypes that mediate nicotine-evoked DA release. A high hit rate was achieved in identifying potent analogues...

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Main Authors: Zhang, Zhenfa, Zheng, Guangrong, Pivavarchyk, Marharyta, Deaciuc, A. Gabriela, Dwoskin, Linda P., Crooks, Peter A.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437627/
https://ncbi.nlm.nih.gov/pubmed/18851914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.09.084
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