Epigenetic Therapy of Non-Small Cell Lung Cancer Using Decitabine (5-Aza-2′-Deoxycytidine)

Epigenetic analysis shows that many genes that suppress malignancy are silenced by aberrant DNA methylation in lung cancer. Many of these genes are interesting targets for reactivation by the inhibitor of DNA methylation, decitabine (5-aza-2′-deoxycytidine, DAC). A pilot study on intense dose DAC sh...

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Bibliographic Details
Main Author: Momparler, Richard L.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2013
Subjects:
Oncology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725836/
https://ncbi.nlm.nih.gov/pubmed/23908969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2013.00188
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