CFTR gene targeting in mouse embryonic stem cells mediated by Small Fragment Homologous Replacement (SFHR)

Different gene targeting approaches have been developed to modify endogenous genomic DNA in both human and mouse cells. Briefly, the process involves the targeting of a specific mutation in situ leading to the gene correction and the restoration of a normal gene function. Most of these protocols wit...

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Hauptverfasser: Sangiuolo, Federica, Scaldaferri, Maria Lucia, Filareto, Antonio, Spitalieri, Paola, Guerra, Lorenzo, Favia, Maria, Caroppo, Rosa, Mango, Ruggiero, Bruscia, Emanuela, Gruenert, Dieter C., Casavola, Valeria, De Felici, Massimo, Novelli, Giuseppe
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725395/
https://ncbi.nlm.nih.gov/pubmed/17981772
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