The Gene Targeting Approach of Small Fragment Homologous Replacement (SFHR) Alters the Expression Patterns of DNA Repair and Cell Cycle Control Genes

Cellular responses and molecular mechanisms activated by exogenous DNA that invades cells are only partially understood. This limits the practical use of gene targeting strategies. Small fragment homologous replacement (SFHR) uses a small exogenous wild-type DNA fragment to restore the endogenous wi...

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Vydáno v:Mol Ther Nucleic Acids
Hlavní autoři: Pierandrei, Silvia, Luchetti, Andrea, Sanchez, Massimo, Novelli, Giuseppe, Sangiuolo, Federica, Lucarelli, Marco
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014528/
https://ncbi.nlm.nih.gov/pubmed/27045208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2016.2
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