Increased cAMP in Monocytes Augments Notch Signaling Mechanisms by Elevating RBP-J and Transducin-like Enhancer of Split (TLE)

In cells of the innate immune system, pathological increases in intracellular cAMP attenuate immune responses and contribute to infections by bacteria such as Bacillus anthracis. In this work, cAMP from B. anthracis edema toxin (ET) is found to activate the Notch signaling pathway in both mouse macr...

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Detalles Bibliográficos
Autores principales: Larabee, Jason L., Shakir, Salika M., Barua, Soumitra, Ballard, Jimmy D.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724613/
https://ncbi.nlm.nih.gov/pubmed/23775085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.465120
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